Instructions

【Ingredients】This product is a compound preparation, and its composition is 0.02 g of Miconazole Nitrate and 0.5 mg of Clobetasol Propionate per gram. 
【Description】 This product is a milky white cream. 
【Indications】For dermatitis, eczema, hand, foot and sputum, femoral hernia and allergic dermatitis caused by fungi. 
【Strength】Compound. 
【Usage and Dosage】External use. Apply the area evenly 1-2 times a day. 
【Adverse Reaction】The drug site can produce irritations such as blisters, erythema, congestion, burning, itching, etc.; folliculitis, skin atrophy and thinning, telangiectasia; can also cause dry skin, hairy, shrinking lines, increased susceptibility to infection, etc. . Long-term large-area medication can cause hypercorrosion, manifested as hairy, hemorrhoids, full moon face, osteoporosis and other symptoms. Even can cause allergic contact dermatitis. 
【Contraindications】
1.Disabled for allergic to corticosteroids and imidazoles. 
2.Skin folds such as the face, eyes, ankles and groin are prohibited. 
【Precautions】 
1.This product contains corticosteroid external preparation. If it is treated for a long time, large area or by capsule, it can cause reversible hypothalamic-pituitary-adrenal (PHA) axis inhibition due to systemic absorption. Some patients It can show the performance of Cushing's syndrome, hyperglycemia and urine sugar. Therefore, this medicine can not be used for a long time, large area, and can not be treated with a packet. 
2.Any systemic use of corticosteroids may reflect adverse reactions including adrenal insufficiency, which may occur when topical corticosteroids are used. Therefore, the use of this product in a large area can not exceed 2 weeks; if the area of medication only accounts for 5%-10% of the body surface, continuous medication for 4 weeks. The dosage per week should not exceed 50g, and systemic adverse reactions are not easy to occur. 
3.If a stimulatory reaction or an allergic reaction occurs during use, the drug should be discontinued and appropriate treatment should be performed. 
4.If accompanied by a skin infection, anti-infective drugs must be used at the same time. If the symptoms of infection are not improved in time, the drug should be discontinued until the infection is controlled. 
5.It is forbidden to use when the medicinal properties change. 
【Pregnant women and lactating women】
1.Pregnant women and lactating women should be used under the guidance of a physician to weigh the pros and cons. 
2.Pregnant women are prohibited from using for a long time and on a large scale. 
【Pediatric Use】For children, such as large-area medication or long-term medication, it will increase the systemic absorption of the drug. Therefore, infants and children should not be used. 
【Geriatric medication】elderly patients with caution. 
【Drug Interactions】are not clear. 
【Drug overdose】Excessive application of this product can cause systemic adverse reactions of adrenocortical hormone, resulting in reversible hypothalamic-pituitary-adrenal (PHA) axis inhibition, some patients may have Cushing syndrome, hyperglycemia and urine sugar . 
【Pharmacology and Toxicology】This product is a compound preparation of miconazole nitrate and clobetasol propionate. Miconazole nitrate is an imidazole antibacterial agent, which has antibacterial action. It can also have bactericidal action when high concentration; it can inhibit the biosynthesis of sterols such as fungal ergosterol; act on fungal cell membrane, damage fungal cell membrane and change its Permeability, loss of important intracellular substances; can also inhibit the biosynthesis of fungal triglycerides and phospholipids; can also inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in cells, leading to fungal subcellular Structural degeneration and necrosis; Candida albicans inhibits the conversion of spores into invasive hyphae. Clobetasol propionate is a highly effective topical corticosteroid with capillary contraction and anti-inflammatory effects. 
【Pharmacokinetics】Miconazole nitrate can penetrate the epidermis and enter the stratum corneum of the skin for a few days, only a small amount of absorption into the whole body; clobetasol propionate can be absorbed through the intact skin after external application, mainly through the liver. Metabolism, excreted from the urine. 
【Storage】shading, sealed, and stored in a cool place (not more than 20 ℃). 
【Package】Aluminum tube packaging,  
【The shelf life】36 months 
【Executive Standard】Chinese Pharmacopoeia(2015) VolumeⅡ.
【Approval No.】GYZZ H35021395 
【Manufacturer】Fujian Pacific Pharmaceutical Co., Ltd.